Lee won the Ladies Scottish Open two years ago at Dundonald. The veteran Park and the rookie van Dam are seeking their first LPGA Tour victories.
Moriya Jutanugarn was one shot back on a sunny day of low scoring at The Renaissance Club, a resort links next to Muirfield on Scotland's East coast. Players were bracing for wind and rain on Friday.
''When I see the forecast, today is like best day and then tomorrow is worst day,'' Lee said. ''So my plan, my kind of plan was I try to make a lot of birdies.''
Van Dam, a long-hitting Dutch player known for viral videos of her swing, hit a 5-iron to 4 feet for eagle on the par-5 first hole and 6-iron to 3 feet for another eagle on the par-5 12th. She wasn't pleased that tees were moved up on several holes, including those where she took full advantage.